Bioprocess Technology

1 Introduction.- 1.1 Biotechnology: A Definition and Overview.- 1.2 Bioprocess Technology.- 2 The Principles of Bioprocess Technology.- 2.1 Empirical Pragmatic Process Development.- 2.2 Basics of Quantification Methods for Bioprocesses.- 2.3 Systematic, Empirical Process Development with Mathematical Models.- 2.4 Mathematical Modeling in Bioprocessing.- 3 Bioreactors.- 3.1 Overview: Industrial Reactors.- 3.2 Systematics of Bioreactors.- 3.3 Quantification Methods.- 3.4 Operational Modes and Bioreactor Concepts.- 3.5 Bioreactor Models.- 3.6 "Perfect Bioreactors" in Bench and Pilot Scale for Process Kinetic Analysis.- 4 Process Kinetic Analysis.- 4.1 Kinetic Analysis in Different Types of Reactors.- 4.2 Regime Analysis-General Concept and Guidelines.- 4.3 Test of Pseudohomogeneity.- 4.4 Parameter Estimation of Kinetic Models with Bioreactors.- 4.5 Modeling Heterogeneous Processes.- 5 Bioprocess Kinetics.- 5.1 Temperature Dependence, k(T), Water Activity, aw, and Enthalpy/Entrophy Compensation.- 5.2 Microkinetic Equations Derived from the Kinetics of Chemical and Enzymatic Reactions.- 5.3 Basic Unstructured Kinetic Models of Growth and Substrate Utilization (Homogeneous Rate Equations).- 5.4 Kinetic Models for Microbial Product Formation.- 5.5 Multisubstrate Kinetics.- 5.6 Mixed Population Kinetics.- 5.7 Dynamic Models for Transient Operation Techniques (Nonstationary Kinetics).- 5.8 Kinetic Models of Heterogeneous Bioprocesses.- 5.9 Pseudokinetics.- 5.10 Kinetics of Sterilization.- 6 Bioreactor Performance: Process Design Methods.- 6.1 The Ideal Single-Stage, Constant-Volume Continuous Stirred Tank Reactor, CSTR (Pseudohomogeneous L-Phase Reactor Model).- 6.2 Variable Volume CSTR Operation (Fed-Batch and Transient Reactor Operation).- 6.3 Multistage Single and Multistream Continuous Reactor Operation..- 6.4 Continuous Plug Flow Reactors (CPFR).- 6.5 Recycle Reactor Operation.- 6.6 Gas/Liquid (Two-Phase) Reactor Models in Bioprocessing.- 6.7 Biofilm Reactor