Chemogenomics in Drug Discovery
A Medicinal Chemistry Perspective
(Sprache: Englisch)
Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics.
This first reference devoted to the topic covers all stages of the early drug discovery process, from...
This first reference devoted to the topic covers all stages of the early drug discovery process, from...
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Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics.
This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design.
With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process.
This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design.
With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process.
KurztextDie Chemogenomik ist eine Brückendisziplin zwischen Chemie und Biologie, die im Rahmen der Suche nach neuen Wirkstoffen Ansätze der kombinatorischen Chemie mit Proteomik und Genomik verbindet. Zwanzig Forschungsgruppen von Universitäten und aus pharmazeutischen Unternehmen erläutern Ihnen in diesem Band alle Schritte der frühen Wirkstoffforschung - von der Wahl des Targets über Verbindungsbibliotheken bis zum Design von Leitstrukturen. Wirkstoffentwickler und medizinische Chemiker, die mit chemogenomischen Methoden arbeiten, werden auf diese umfangreiche und kompetente Informationsquelle nicht verzichten wollen.
Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics.
This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design.
With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process
Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics.
This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design.
With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process
Inhaltsverzeichnis zu „Chemogenomics in Drug Discovery “
From the contents:IntroductionTARGET FAMILIESGPCRsKinasesNuclear Hormone ReceptorsIon ChannelsPhosphodiesterasesMEDICINAL CHEMISTRY STRATEGIESPrivileged StructuresNatural ProductsDiversity-oriented Organic ChemistrySOSA ApproachTemplate Hopping and Designed Combinatorial ChemistryChemogenomics on a Building Block LevelBinding Site SimilaritiesBioinformatics Meets ChemoinformaticsProteochemometrics
Autoren-Porträt
Hugo Kubinyi gehört seit 1985 der BASF AG an, wo Kombinatorische Chemie, Molecular Modelling und Wirkstoffdesign zu seinen Tätigkeitsfeldern zählten. Sein Spezialgebiet sind Struktur-Wirkungs-Beziehungen und QSAR-Methoden.
Bibliographische Angaben
- 2004, 380 Seiten, 200 Abbildungen, Gebunden, Englisch
- Herausgegeben: Hugo Kubinyi, Gerhard Müller, Raimund Mannhold
- Verlag: Wiley-VCH
- ISBN-10: 352730987X
- ISBN-13: 9783527309870
Sprache:
Englisch
Rezension zu „Chemogenomics in Drug Discovery “
"... this book provides up-to-date insights into the world of chemogenomics. Most chapters are of excellent quality, providing numerous and diverse contributions from industrial practice. >Chemogenomics in Drug Discovery< offers a practical definition of chemogenomics in order to foster a clear understanding of this genome-wide drug-discovery approach."Thomas Klabunde, Sanofi-Aventis, Frankfurt, ChemBioChem, 4/2005
"The contributions in >Chemogenomics in Drug Discovery< are of very high quality and are clearly presented ... All chapters have a high scientific value, and collectively they contribute a great deal to the understanding of how chemogenomics and scaled-up medicinal chemistry can support the early stages of drug discovery. Therefore, this work is highly relevant for everyone with an intereste in modern drug development, and especially for readers in the pharmaceutical industry."
Ulf Börjesson, Institute of Pharmaceutical Chemistry, University of Marburg, Angewandte Chemie, IE, 3rd May Issue 2005-44/19+ Angewandte Chemie, 3. Maiheft 2005-117/19
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