Chiral Amine Synthesis

Preface
STEREOSELECTIVE SYNTHESIS OF ALPHA-BRANCHED AMINES BY NUCLEOPHILIC ADDITION OF UNSTABILIZED CARBANIONS TO IMINES
Introduction
Overview of the Methods for the Preparation of Imines
Chiral Auxiliary-Based Approaches
Catalytic Asymmetric Nucleophilic Addition to Achiral Imines
Conclusion
ASYMMETRIC METHODS FOR RADICAL ADDITION TO IMINO COMPOUNDS
Background and Introduction
Intermolecular Radical Addition Chiral N-Acylhydrazones
Asymmetric Catalysis of Radical Addition
Closing Remarks
ENANTIOSELECTIVE SYNTHESIS OF AMINES BY CHIRAL BRONSTED ACID CATALYSTS
Introduction
Carbon-Carbon Bond Forming Reactions
Carbon-Hydrogen Bond Forming Reactions
Carbon-Heteroatom Bond Forming Reactions
Conclusion
REDUCTION OF IMINES WITH TRICHLOROSILANE CATALYZED BY CHIRAL LEWIS BASES
Introduction
Formamides as Lewis-Basic Organocatalysts in Hydrosilylation of Imines
Other Amides as Organocatalysts in Hydrosilylation of Imines
Sulfinamides as Organocatalysts in Hydrosilylation of Imines
Supported Organocatalysts in Hydrosilylation of Imines
Mechanistic Considerations
Synthetic Applications
Conclusions
Typical Procedures for the Catalytic Hydrosilylation of Imines
CATALYTIC, ENANTIOSELECTIVE; VINYLOGOUS MANNICH REACTIONS
Introduction
Vinylogous Mukaiyama-Mannich Reactions of Silyl Dienolates
Direct Vinylogous Mannich Reactions of Unmodified Substrates
Miscellaneous
Conclusion
CHIRAL AMINES FROM TRANSITION-METAL-MEDIATED HYDROGENATION AND TRANSFER HYDROGENATION
Scope and Related Publications
Chiral Amines with a Disubstituted Nitrogen Atom, HNR*R1
Chiral Amines with Trisubstituted Nitrogen, NR*R1R2
Conclusion
ASYMMETRIC REDUCTIVE AMINATION
Introduction
Transition Metal-Mediated Homogenous Reductive Amination
Enantioselective Organocatalytic Reductive Amination
Diastereoselective Reductive Amination
Conclusions
ENANTIOSELECTIVE HYDROGENATION OF ENAMINES WITH MONODENTATE PHOSPHORUS LIGANDS
Introduction
Asymmetric Hydrogenation of

Tom Nugent gained his Ph.D. in Organic Chemistry in 1995 from Virginia Tech working with Professor Tomas Hudlicky. From 1996-1997, he completed his postdoctoral studies at the University of Liverpool (Great Britain) with Professor Stanley Roberts.
Over the next six years he worked as a process research chemist, first with Catalytica Fine Chemicals / DSM (Mountain View, California, 1998-2000) and then with Pharmacia/Pfizer Corporation (South San Francisco, California, 2001-2003). In 2004 he began his academic career at Jacobs University as Assistant Professor of Organic Chemistry.