Cholera Toxins
(Sprache: Englisch)
Vibrio cholerae, the causative organism of the disease Cholera, colonizes the small intestine and produces several different toxins among which the enterotoxin, or more widely known as cholera toxin (CT), happens to be the major virulence determinant that...
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Vibrio cholerae, the causative organism of the disease Cholera, colonizes the small intestine and produces several different toxins among which the enterotoxin, or more widely known as cholera toxin (CT), happens to be the major virulence determinant that is responsible for the diarrheal syndrome. This book provides for the first time comprehensive and up-to-date information about all the toxins of Vibrio cholerae, their physical and chemical structures, their biosynthesis and its genetic regulation, their physiology, the molecular biology of their interactions with the host as well as their role in the development of an appropriate and effective cholera vaccine. It also offers relevant and necessary background information on the basic biology of the Vibrio cholerae cell and cholera bacteriophages.
Klappentext zu „Cholera Toxins “
To start with, we feel that we should explain why the book has been entitled Cholera Toxins. In fact, the enterotoxin secreted by Vibrio cholerae, which is p- marily responsible for causation of the disease, is conventionally known as or referred to as cholera toxin, or CT. By using the word "toxins" (in its plural form), we wanted to cover all of the different types of toxins-and not just CT-produced by V. cholerae. We could have used the title Toxins of Vibrio cholerae, but we believe that Cholera Toxins is simpler and equally as expressive. However, due to its relative importance, the story of CT covers most of this book. Also, compared to all other toxins of V. cholerae, CT has been investigated more extensively. This book was jointly written by us. It is not a multiauthor book in which each expert writes one chapter. In that respect our task is harder. On the other hand, it has given us the unique opportunity to present the entire subject in the way that we conceived it. Besides, our objective is to cater to the needs of not only active research scientists but also students from different disciplines-microbiology, molecular physiology and pharmacology, basic medicines, etc. -and as such, we have attempted to present the subject in a way that will be appreciated by general readers. Further, we have provided some information that students and predoctoral researchers may find useful at the end of the book.
Inhaltsverzeichnis zu „Cholera Toxins “
An Introduction to Cholera.- Bacterial Toxins: A Brief Overview.- Vibrio cholerae, the Causative Organism.- Endotoxin of Vibrio cholerae: Physical and Chemical Characterization.- Endotoxin of Vibrio cholerae: Genetics of Biosynthesis.- Endotoxin of Vibrio cholerae: Biological Functions.- Cholera Toxin (CT): Structure.- Cholera Toxin (CT): Organization and Function of the Relevant Genetic Elements.- Cholera Toxin (CT): Regulation of the Relevant Virulence Genes.- Cholera Toxin (CT): Secretion by the Vibrios.- Cholera Toxin (CT): Entry and Retrograde Trafficking into the Epithelial Cell.- Cholera Toxin (CT): Immune Response of the Host and Vaccine Production.- Other Toxins of Vibrio cholerae.- Concluding Notes.
Autoren-Porträt von Keya Chaudhuri, S. N. Chatterjee
Dr. Keya Chaudhuri (b. 1952) obtained her PhD degree from Jadavpur University in 1983 and is presently working as Senior Scientist & Deputy Director at the Molecular & Human Genetics Division of the Indian Institute of Chemical Biology, Kolkata, India. Her research focuses on Vibrio cholerae infection, mainly on the cellular and molecular mechanisms of the disease-process, with special emphasis on the identification of bacterial gene products that become apparent during the infection as well as their role in V. cholerae pathogenesis and the elucidation of host response at the molecular level. Besides Vibrio cholerae, her research interest includes bioinformatics and cancer biology.
Bibliographische Angaben
- Autoren: Keya Chaudhuri , S. N. Chatterjee
- 2009, XIV, 321 Seiten, Masse: 16 x 24,1 cm, Gebunden, Englisch
- Verlag: Springer, Berlin
- ISBN-10: 3540884513
- ISBN-13: 9783540884514
- Erscheinungsdatum: 10.02.2009
Sprache:
Englisch
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