Classics in Stereoselective Synthesis

MACROCYCLIC STEREOCONTROL
Introduction
Background
Conformational Control in Medium-Sized Rings
Asymmetric Synthesis with Medium-Sized Rings
Case Studies in Natural Products Total Synthesis
Macrocyclic Stereocontrol in Cyclic Peptides
Appendix: Macrocycle Formation
CARBONYL ADITION REACTIONS
Introduction
Non-Chelated 1,2-Asymmetric Induction and the Operation of Steric and Electronic Effects
1,2-Asymmetric Induction Predicated on Chelation Control
1,3-Asymmetric Induction from CBeta Stereogenic Centers
Asymmetric Induction by Remote Stereocenters (Beyond 1,3-Induction)
Catalytic Enantioselective Carbonyl Additions of Arganozinc Species
Enantioselective Ketone Reduction
Enzymatic Reduction of Ketones
Enantioselective Formation of Cyanohydrins
Enantioselective Alkyne Additions
Asymmetric Carbonyl-Ene Reactions
ALPHA-FUNCTIONALIZATIONS OF ENOLATES
Introduction
Diastereoselective Alpha-Alkylations of Chiral Enolates
Heteroatom-Substituted Enolates
Asymmetric Enolate Alkylations Using Chiral Auxiliaries
Enantioselective Enolate Alkylations
Alpha-Hydroxylations of Enolates
Alpha-Halogenations of Enolates
ALDOL REACTIONS
Introduction
Chiral Enolates Through the Use of Chiral Auxiliaries or Chiral Controller Groups
Substrate Control with Chiral Carbonyl Compounds
Catalytic Enantioselective Aldol Reactions
ALLYLATIONS OF C=O BONDS
Introduction
Reactivity of Allylmetal Reagents
Boronate Additions
Enantioselective Additions of Optically Active Allylic Boron Reagents
Diastereoselecive Allylations with Chiral Boron Reagents
Mechanistic Aspects - Lewis Acid-Promoted Addition of Allylsilanes and Allylstannanes to Aldehydes
Chelation Control in the Allylation of Alpha- and Beta-Alkoxy Aldehydes
Allylchromium Reagents
Diastereoselective Allylations with Chiral Silanes and Stannanes
Catalytic Asymmetric Allylations
CHIRAL ACETALS
Introduction
Diastereoselective Reactions of Chiral Acetals
Glycosylations
Spiroketals in Natural Product

Professor Carreira obtained his Ph.D. degree in 1990 from Harvard University and became Assistant Professor at the same faculty in 1992. After becoming full professor in 1997 he moved to ETH Zürich in 1998. He is recipient of many awards among them the Nobel Laureate Signature Award and the ACS Award in Pure Chemistry. His research focuses on asymmetric synthesis of natural products.

Dr. Lisbet Kvaerno received her PhD in 2004 and worked as a Postdoc at the ETH Zuerich, Switzerland in the group of Erick M. Carreira. After a second postdoctoral stay at Harvard in he group of David A. Evans she moved to Germany where she is currently an Independent Junior Group Leader at the Max Planck Institute of Coal Research. Research in her group is focused on organic synthesis and the discovery of new reaction methodology, in particular stereoselective and catalytic asymmetric reactions.

"The book provides a collection of classic methods for stereoselective synthesis that have been developed over the past two decades - methods that should be at the command of every modern practitioner of synthetic organic chemistry." (Booknews, 1 April 2011)

"The book provides a collection of classic methods for stereoselective synthesis that have been developed over the past two decades - methods that should be at the command of every modern practitioner of synthetic organic chemistry." (Booknews, 1 April 2011)