Classics in Total Synthesis IV

1. Introduction: Total Synthesis Marching on with New Methods and Strategies and with Molecules for Biology and Medicine 2. Halichondrin B and Norhalichondrin B 3. Daphmanidin E 4. Epicoccin G and (-)-Acetylaranotin 5. Taiwaniadducts B, C, and D 6. Schindilactone A 7. Welwitindolinones 8. Ryanodine and Ryanodol 9. Gedunin, Mitrephorone A, and Antiretroviral Agent Islatravir 10. Trioxacarcins 11. Aplyviolene 12. Dixiamycin B 13. Ingenol 14. Cardamom Peroxide, Nodulisporic Acid C, and Bilobalide 15. Batrachotoxin and Conidiogenones 16. Gukulenin B and C-H Functionalization

K.C. Nicolaou holds the Harry C. and Olga K. Wiess Chair in Natural Sciences at Rice University (Houston, USA). He was born in Cyprus and educated in the UK and USA. The impact of his work in chemistry, biology, and medicine flows from his contributions to chemical synthesis as described in over 800 publications, 79 patents, and five books, including the popular Classics in Total Synthesis (1996, VCH), Classics in Total Synthesis II (2003, Wiley-VCH), Classics in Total Synthesis III (2011, Wiley-VCH), and Molecules That Changed the World (2008, Wiley-VCH). He is the recipient of numerous prizes, awards and honors (e.g., Nemitsas Prize, Wolf Prize, and the Robert Koch Gold Medal) and has been elected to several academies, such as the New York Academy of Sciences, the American Academy of Arts and Sciences, the American Philosophical Society, the Royal Society of London, the National Academy of Sciences (USA), the Royal Society of Chemistry (UK), the Cyprus Academy of Sciences, Letters and Arts, and the German Academy of Sciences Leopoldina. His dedication to chemical education is evidenced by his training of hundreds of graduate students and postdoctoral fellows.
 
Ruocheng Yu is a postdoctoral fellow in the group of Prof. Emily Balskus at Harvard University (Cambridge, USA). He studied chemistry at Peking University (China), where he received his B.S. degree under the supervision of Profs. Zhen Yang and Jiahua Chen in 2012 before he went to pursue his doctoral studies under the guidance of K.C. Nicolaou at the Scripps Research Institute (La Jolla, USA) and later Rice University (Houston, USA). He graduated in 2017 and stayed in K.C. Nicolaou's group as a postdoctoral research scientist until 2023.
 
Stephan Rigol is a postdoctoral fellow in K.C. Nicolaou's research group at Rice University (Houston, USA). He was educated at Leipzig University (Germany), where he obtained his undergraduate degrees and received his doctorate in 2013 under the guidance of