Energy Metabolism and Obesity

Molecular Physiology of Monogenic and Syndromic Obesities in Humans.- Leptin Signaling In the Brain.- Inactivating Melanocortin 4 Receptor Mutations and Human Obesity.- The Role of Central Melanocortins in Cachexia.- The Efferent Arm of the Energy Balance Regulatory Pathway: Neuroendocrinology and Pathology.- Adiponectin: A Multifunctional Adipokine.- The Role of the Gastrointestinal Hormones Ghrelin, Peptide YY, and Glucagon-like Peptide-1 in the Regulation of Energy Balance.- The Role of Growth Hormone Secretagogues and Ghrelin in Feeding and Body Composition.- Interaction Between Physical Activity and Genetic Factors in Complex Metabolic Disease.- 11?-Hydroxysteroid Dehydrogenase Type 1 and Obesity.- Prader-Willi Syndrome: A Model of Disordered Energy Homeostasis.- Antipsychotic Medication-Induced Weight Gain and Risk for Diabetes and Cardiovascular Disease.- Treatment of Insulin Resistance in Youth: The Role of Metformin.- The Surgical Approach to Morbid Obesity.

Energy Metabolism and Obesity presents an up-to-date overview of the many aspects of energy balance and its relationships to disease processes resulting from excess energy consumption and storage. Topics covered include energy storage and partitioning, control of feeding and physical activity, adipocyte biology, and the development of obesity-related comorbidities.

From the reviews:



"This is a comprehensive review of the current scientific knowledge of the myriad factors that play a role in the development of obesity ... . Readers from many levels will find this review helpful, including students, researchers, and others seeking to get an overview of the state of the science of obesity-related research. In addition, practitioners seeking an understanding of the direction in which obesity treatment might be moving will also find this book helpful." (Robert Michael Sargis, Doody's Review Service, February, 2008)

"This is ... a number of valuable up to date information written by recognized experts. ... All chapters are illustrated by several tables, figures, schemes, photos and color plates of high instructive value and supported by more than 1500 references which considerably increase the information level of this monograph and offer to the reader a ... deeper study of individual topics. ... obesitologists, diabetologists, endocrinologists and several other experts of special related fields will consider this monograph as one of valuable acquisition of their library." (Endocrine Regulations, February, 2008)

"This book presents in 14 chapters written by US experts, a compilation of critical articles on topics related to energy metabolism and obesity. The titles include reviews on leptin, adiponectin, melanocortin, gastrointestinal hormones, growth hormone and ghrelin. Topics related to obesity include syndromic obesities, Prader Willi syndrome, antipsychotic drugs, as well as the surgical approach to obesity. Concise and clearly written overviews. For clinicians and researchers." (Pediatric Endocrinology Reviews, Vol. 5 (3), March, 2008)

"Dr. Donohue's book is organized into 14 chapters and each is authored by a leader in the field. Each chapter is comprehensive and can serve as an independent reference for its specific topic ... . In summary, Dr. Donohue has constructed