Experimental Models of Cardiovascular Diseases

Decellularized extracellular matrix for modelling cardiac extracellular microenvironment.- Subtype and lineage- mediated protocol for standardizing activin/nodal and BMP signaling for hiPSC-derived cardiomyocyte differentiation.- Generation of 3D-multicellular human iPSC-heart organoids for the non-invasive assessment of cardiac fibrosis.- In vitro experimental approach for studying human pulmonary artery smooth muscle cells and endothelial cells proliferation and migration.- Culturing cardiac tissue slices under continuous physiological mechanical stretches.- Quantitative assessment of mitochondrial morphology and electrophysiological function in the diabetic heart.- Ex vivo working porcine heart model.- Conventional Method of Cardiac Ischemia/Reperfusion Injury in Mice.- Rat model of Isoproterenol-induced myocardial injury.- Pop-out Myocardial Infarction Induction in Mice.- Rat Models of Cardiorenal Syndrome and Methods for Functional Assessment.- The Sugen/Hypoxia rat model for pulmonary hypertension and right heart failure.- Unilateral lung removal in combination with monocrotaline or SU5416 in rodents: a reliable model to mimic the pathology of the human pulmonary hypertension.- Swine model of myocardial infarction induced by ischemia-reperfusion and embolization.- Porcine Model of Hypertrophy-Independent Left Ventricular Stiffening via Repetitive Pressure Overload.- Swine model of coronary artery dissection.- Hypoxia-induced piglet model of cardiac arrest with assisted resuscitation by extracorporeal membrane oxygenation.- A dynamic sheep model to induce pulmonary hypertension and right ventricular failure.