Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist

Introduction.- Historical Overview of Pediatric HSCT.- Brief Introduction to the Basic Scientific Principles of Hematopoietic Stem Cell Transplantation (HSCT).- Pretransplantation: Indications and Timing.- Spotlight on Minimal Residual Disease (MRD): Impact of MRD on HSCT Outcomes for Pediatric Leukemia.- HSCT Recipient Pretransplantation Evaluation.- How to Select a Donor and Hematopoietic Stem Cell Source: Related versus Unrelated Donors for Allogeneic HSCT.- Donor Evaluation, Selection and Hematopoietic Stem Cell Mobilization, Procurement and Manipulation.- Preparing the Patient for HSCT: Conditioning Regimens and their Scientific Rationale.- Engraftment and Chimerism.- Graft Failure.- Engraftment Syndrome and Associated Cytokine Storm and Capillary Leak Syndrome.- Nutrition in the Peri-HSCT Period.- Mucositis and Pain in the Peri- HSCT Period.- Hepatoxicity in the Peri- HSCT Period.- Renal Toxicities in the Peri-HSCT Period.- Infectious Complications and HSCT.- Acute Graft-Versus-Host Disease: Diagnosis, Prophylaxis, and Treatment.- Chronic GVHD.- Hematologic Complications Associated with HSCT.- Pulmonary Complications Associated with HSCT.- Renal Complications Associated with HSCT.- Cardiac Complications Associated with HSCT.- Neurologic and Sensory Complications Associated with HSCT.- HSCT-Associated Complications of the Skin, Hair and Nails.- Immune Reconstitution after Hematopoietic Stem Cell Transplantation.- Life After HSCT: Survivorship and Long-Term Issues.- Medications commonly Used in Pediatric HSCT.

Valerie I. Brown, MD, PhD

Director, Experimental Therapeutics, Pediatric Hematology/Oncology

Director, Pediatric Hematology/Oncology Fellowship Program

Penn State Milton S. Hershey Medical Center and Children's Hospital, Division of Pediatric Oncology/Hematology, Hershey, PA, USA