High-Throughput Screening Assays in Toxicology

Monitoring Ligand-Activated Protein-Protein Interactions Using Bioluminescent Resonance Energy Transfer (BRET) Assay.- Mitochondrial Membrane Potential Assay.- Using beta-Lactamase and NanoLuc Luciferase Reporter Gene Assays to Identify Inhibitors of the HIF-1 Signaling Pathway.- Quantitative High-Throughput Luciferase Screening in Identifying CAR Modulators.- Transactivation and Coactivator Recruitment Assays for Measuring Farnesoid X Receptor Activity.- Cell-Based Assay for Identifying the Modulators of Antioxidant Response Element Signaling Pathway.- Study Liver Cytochrome P450 3A4 Inhibition and Hepatotoxicity Using DMSO-Differentiated HuH-7 Cells.- Determination of Histone H2AX Phosphorylation in DT40 Cells.- High-Throughput and High Content Micronucleus Assay in CHO-K1 Cells.- Better, Faster, Cheaper: Getting the Most Out of High-Throughput Screening with Zebrafish.- Fast Functional Germline and Epigenetic Assays in the Nematode .- A Quantitative High-Throughput Screening Data Analysis Pipeline for Activity Profiling.- Correction of Microplate Data from High-Throughput Screening.- CurveP Method for Rendering High-Throughput Screening Dose-Response Data into Digital Fingerprints.- Accounting Artifacts in High-Throughput Toxicity Assays.- Accessing the High-Throughput Screening Data Landscape.- Curating and Preparing High Throughput Screening Data for Quantitative Structure Activity Relationship Modeling.