Molecular Basis of Thyroid Cancer

- Preface

1. The origin of cancer, Evan Y. Yu and William C. Hahn
2. The pathology of thyroid cancer; Sylvia L. Asa
3. Thyroid lymphomas; Runjan Chetty
4. Molecular events in follicular thyroid tumors; Todd G. Kroll
5. Molecular epidemiology of thyroid cancer; Martin Schlumberger
6. Growth factors and their receptors in the genesis and treatment of thyroid cancer; Shereen Ezzat
7. Biology of Ras in thyroid cells; Judy L. Meinkoth
8. P53 and other cell cycle regulators; Nadir R. Farid
9. Abnormalities of nuclear receptors in thyroid cancer; Sheue-Yann Cheng
10. Matrix metalloproteinases in thyroid cancer; Yufei Shi and Minjing Zou
11. The molecular pathways induced by radiation and leading to thyroid carcinogenesis; Yuri E. Nikiforov
12. TRK oncogenes in papillary thyroid carcinoma; Angela Greco, Emanuela Roccato and Marco A. Pierotti
13. Thyroidal iodide transport and thyroid cancer; Orsolya Dohán and Nancy Carrasco
14. Molecular signaling in thyroid cancer; Nicholas J. Sarlis and Salvatore Benvenga
15. Gene expression in thyroid tumors; Laszlo Puskas and Nadir R. Farid
16. Animal models of thyroid carcinogenesis; Carsten Boltze
17. Diagnostic molecular markers in thyroid cancer; Matthew D. Ringel
18. Thyroid cancer imaging; T.T.H. Phan, P.L. Jager, K.M. van Tol, T.P. Links
19. Past, presence and future of thyroid-stimulating hormone (TSH) superactive analogs; Mariusz W. Szkudlinski
20. Pathobiology of antineoplastic therapy in undifferentiated thyroid cancer; Kenneth B. Ain
21. Gene therapy for thyroid cancer; Yuji Nagayama
22. Familial papillary thyroid carcinoma; Carl D. Malchoff and Diana M. Malchoff
23. RET activation in medullary carcinomas; Marco A. Pierotti, Elena Arighi, Debora Degl'Innocenti and Maria Grazia Borrello
24. From genes to decisions; Lois M. Mulligan

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Reviewer's Expert Opinion: Ronald N Cohen, MD (University of Chicago Medical Center)



This book discusses and evaluates recent advances in the molecular basis of the pathogenesis and treatment of the various forms of thyroid cancer. The purpose is to convey a better understanding of the factors that cause thyroid cancer, as well as to explore novel strategies for its treatment, focusing on recent advances in molecular biology. There is a significant, and rapidly-growing, literature concerning the molecular biology of thyroid cancer, and this book is a welcome addition that allows these novel findings to be placed in perspective. There will be a relatively narrow audience for this book. In particular, it will appeal significantly more to thyroidologists than to general endocrinologists. In addition, it will be interesting to nuclear medicine physicians, pathologists, and oncologists if they have a specific interest in thyroid cancer. The book covers a wide range of topics, ranging from the pathology of thyroid tumors to specific molecular events in the pathogenesis of thyroid cancer. In this process, chapters devoted to specific molecules important in thyroid cancer are included. In addition, information on NIS, and how it relates to thyroid cancer imaging and treatment is discussed in detail. Finally, molecular genetics, for example the genetics of medullary thyroid cancer, is also included. The chapters are well written and informative, though there is occasional overlap. For physicians and scientists with a significant interest in thyroid cancer, this book is a welcome addition. It provides a wealth of interesting information, and I enjoyed it very much.