Organic Stereochemistry

Foreword: D. SeebachPreface: The EditorsPart 1: Symmetry Elements and Operations, Classification of Stereoisomers (B. Testa, G. Vistoli, and A. Pedretti)Part 2: Stereoisomerism Resulting from One or Several Stereogenic Centers (B. Testa)Part 3: Other Stereogenic Elements: Axes of Chirality, Planes of Chirality, Helicity, and (E,Z)-Diastereoisomerism (B. Testa)Part 4: Isomerisms about Single Bonds and in Cyclic Systems (B. Testa, G. Vistoli, and A. Pedretti)Part 5: Stereoselectivity in Molecular and Clinical Pharmacology (B. Testa, G. Vistoli, A. Pedretti, and J. Caldwell)Part 6: The Conformation Factor in Molecular Pharmacology (G. Vistoli, B. Testa, and A. Pedretti)Part 7: The Concept of Substrate Stereoselectivity in Biochemistry and Xenobiotic Metabolism (B. Testa)Part 8: Prostereoisomerism and the Concept of Product Stereoselectivity in Biochemistry and Xenobiotic Metabolism (B. Testa)Part 9: Molecular Chirality in Chemistry and Biology: Historical Milestones (J. Gal)GlossaryIndex

Bernard Testa is Emeritus Professor of the University of Lausanne, having served there for 25 years as a full professor of medicinal chemistry. He has written 6 books and edited 33 others, and (co)-authored well over 450 research and review articles in the fields of drug design and drug metabolism. Between 1994 and 1998, he was the European Editor of Pharmaceutical Research, and is now a Senior Editor of Chemistry & Biodiversity, as well as serving on the editorial boards of several leading journals. Professor Testa holds honorary doctorates from the universities of Milan, Montpellier, and Parma, and is a recipient of the Nauta Award on Pharmacochemistry given by the European Federation for Medicinal Chemistry.John Caldwell trained in biochemical pharmacology at St. Mary's Hospital Medical School in London, where he held various academic positions from 1972, becoming a full professor in 1987 and Dean of the Medical School in 1995. After St. Mary's merger with Imperial College in 1997, he served as the head of Biomedical Sciences and head of the Medical School. In 2002 he moved to the University of Liverpool to become Dean of the Faculty of Medicine and, additionally, a Pro-Vice-Chancellor in 2007. He stepped down as Dean in 2010 and continues on as a Pro-Vice-Chancellor. He is particularly well known for his investigations of the importance of the application of stereochemistry to the development of more effective drugs. He founded the interdisciplinary journal Chirality in 1989 and remains as Editor-in-Chief. Among many honours and distinctions, he has been the president of the International Society for the Study of Xenobiotics and the Sterling-Winthrop Distinguished Professor at the University of Michigan. He became an honorary member of the Royal College of Physicians in 1998. He is a board member of a number of companies and serves at director level in the UK National Health Service.M. Volkan Kisakürek received his Ph.D. in Organic Chemistry at the