Organism Models of Autism Spectrum Disorders

Organism Models: Choosing the Right Model.- The Autistic Spectrum Disorders (ASD) : From the Clinics to the Molecular Analysis.- Selecting the Right Species: Practical Information on Organism Models.- Viewing Animal Models for Tuberous Sclerosis Complex in the Light of Evolution.- In Vivo Imaging in Mice.- Invertebrate Models of Synaptic Transmission in Autism Spectrum Disorders.- Epigenetic Factors in Normal and Pathological Neuronal Development.- Finding Endophenotypes for Autism Spectrum Disorders (ASD): cDNA Microarrays and Brain Transcripts.- Serotonin Disturbance in Mouse Models of Autism Spectrum Disorders.- Communication and Language in Animals.- Social Relationships in Nonhuman Primates: Potential Models of Pervasive Disorders.- Zebrafish Social Behaviour Testing in Developmental Brain Disorders.- Maintaining Mice for Neurobehavioral Examination.- Deficit in Social Relationships and Reduced Field of Interest in Mice.- Modeling Autism Spectrum Disorders Motor Deficits in Mice.- Neuro-Behavioral Testing of Mouse Models of Rett Syndrome.- Mouse Models of Tuberous Sclerosis.- Use of the Zebrafish Model to Understand Behavioral Disorders Associated with Altered Oxytocin System Development: Implications for Autism and Prader-Willi Syndrome.- Epilogue: Perspectives and Caveats.

"Aims to assist readers in contemplating and selecting a species to model a circumscribed aspect of the illness, such as a mutation or a neuronal network problem. ... Each chapter concludes with citations from the scientific literature which are both timely and relevant. This is an interesting and informative book on modeling aspects of ASD. Researchers in the field will find the approach to studying ASD refreshing and hopeful. This is a valuable contribution to this area of study." (Michael Joel Schrift, Doody's Book Reviews, May, 2015)