Protein Tyrosine Phosphatases

 Induction of Translational Readthrough on Protein Tyrosine Phosphatases Targeted by Premature Termination Codon Mutations in Human Disease.- Understanding Pseudophosphatase Function through Biochemical Interactions.-    CRISPR/Cas9-Mediated Modification of PTP Expression.- Osteoclast Methods in Protein Phosphatase Research.- OT-I TCR Transgenic Mice to Study the Role of PTPN22 in Anti-Cancer Immunity.- Protein-Tyrosine Phosphatases Studied in Zebrafish.- Examining Phosphatases through Immunofluorescent Microscopy.- Identification of Protein Tyrosine Phosphatase (PTP) Substrates.- Kinase-Catalyzed Biotinylation to Identify Phosphatase Substrates (K-BIPS).- Systems-Level Analysis of the Effects of RPTPs on Cellular Signaling Networks.- Detection of Protein Tyrosine Phosphatase Interacting Partners by Mass Spectrometry.- Detecting PTP Protein-Protein Interactions by Fluorescent Immunoprecipitation Analysis (FIPA).- Identifying Transmembrane Interactions in Receptor Protein Tyrosine Phosphatase Homodimerization and Heterodimerization.- Preparation of Oxidized and Reduced PTP4A1 for Structural and Functional Studies.- Measuring the Reversible Oxidation of Protein Tyrosine Phosphatases using a Modified Cysteinyl-Labeling Assay.- Identification and Optimization of Protein Tyrosine Phosphatase Inhibitors via Fragment Ligation.- Targeting Non-Conserved and Pathogenic Cysteines of Protein Tyrosine Phosphatases with Small Molecules.- In Vitro Phosphatase Assays for the Eya2 Tyrosine Phosphatase.- High Throughput Discovery and Characterization of Covalent Inhibitors for Protein Tyrosine Phosphatases.