Purines in Cellular Signaling

the Adenosine A2 Receptor via Molecular Modeling Techniques.- 25 Physiological and Biochemical Aspects of "P"-Site-Mediated Inhibition of Adenylyl Cyclase.- 26 Adenosine Receptors Mediating Inhibition of Peripheral and Central Neurons.- 27 Adenosine Receptors as Drug Targets: Fulfilling the Promise?.- 28 Mechanisms of Adenosine Action.- 29 Functional Roles of A1 and A2 Receptors in Rat Hippocampus and Striatum.- 30 Subclassification of Neuronal Adenosine Receptors.- 31 Effects of Adenosine on Mast Cells.- 32 The Role of Adenosine on the Gastric Acid Secretory Response.- 33 Adenosine Receptors and Signaling in the Kidney.- 34 Inhibition of the Function of Guanine Nucleotide Binding Proteins by the New Positive Inotropes.- 35 Blockade of Antigen Activated Signals by Xanthine Analogs in RBL-2H3 Cells:Evidence for a Novel Adenosine Receptor.- Section 2: Adenine Nucleotide Receptors and Effector Systems.- 36 Classification and Characterization of Purinoceptors.- 37 Structure Activity Relationships for Adenine Nucleotide Receptors on Mast Cells, Human Platelets, and Smooth Muscle.- 38 Modulation of Norepinephrine Release by ATP and Adenosine.- 39 The Phospholipase C Linked P2y-Purinergic Receptor.- 40 Roles of an ADP Receptor on the Platelet Surface in Mediating Aggregation and Fibrinogen Binding.- Section 3: Phosphodiesterase Enzymes and Inhibitors.- 41 Structural and Functional Characterization of Cyclic GMP-Stimulated Phosphodiesterases and Their Role in Intracellular Signal Transduction.- 42 Phosphodiesterase Genes from Flies to Mammals.- 43 Structure and Function of the High Affinity, Rolipram and RO 2-1724 Sensitive, cAMP Phosphodiesterases.- 44 Correlation of 3H-Rolipram Binding to a Cerebral cAMP Phosphodiesterase with Antidepressant Activity.- 45 Mechanism for Dual Regulation of the Particulate cGMP-Inhibited cAMP Phosphodiesterase in Rat Adipocytes by Isoproterenol and Insulin.- 46 Expression of Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterase in Developing and Adult Rat Brain.- 47 Regulation of cAMP Metabolism in PC12 Cells by Type II (cGMP-Activatable) Cyclic Nucleotide Phosphodiesterase.- 48 cGMP-Binding Phosphodiesterase: Novel Effects of cGMP Binding on the Interaction Between Functional Domains in the Enzyme.- 49 Clinical Investigations with Phosphodiesterase Inhibitors.- 50 Chemical Probes of Type IV Phosphodiesterase: Design, Synthesis, and Characterization of (3H)-2Y186126 as a Radioligand for Sites Within Cardiac Membranes.- 51 Purification of a cGMP-inhibited cAMP Phosphodiesterase from Vascular Smooth Muscle.- 52 Low KmcAMP Phosphodiesterase Isozymes and Modulation of Tone in Vascular, Airway and Gastrointestinal Smooth Muscle.- 53 Structure Activity Relationships of Xanthines as Inhibitors of Cyclic Nucleotide Phosphodiesterases and as Antagonists of Adenosine Receptors.- 54 Mechanisms of Xanthine Actions in Models of Asthma.- Section 4: Abstracts.- A Intracellular and Extracellular Metabolism of Adenosine and Adenine Nucleotides.- B Molecular Probes for Purinoceptors.- C Phosphodiesterases - Multiples Forms and Regulation.- D The Physiological Effects of Adenosine and Adenine Nucleotides.- E Structure Activity Relationships at Adenosine and ATP Receptors.- F Effector Systems for Modulation of Biological Response by Purines.- G Phosphodiesterase Inhibitors - Mechanisms and Structure Activity Relationships.- Author Index.