Resistance to Molecular Therapies for Hepatocellular Carcinoma
(Sprache: Englisch)
This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment...
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This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies. Inhaltsverzeichnis zu „Resistance to Molecular Therapies for Hepatocellular Carcinoma “
Tumor Heterogeneity and Resistance to Targeted Therapies in Hepatocellular Carcinoma.- Modulating Immune Responses to Overcome Resistance in Hepatocellular Carcinoma.- Role of Tumor Microenvironment in Hepatocellular Carcinoma Resistance.- Contribution of the Cancer Stem Cell Phenotype to Hepatocellular Carcinoma Resistance.- Clinical and Preclinical Perspectives on Mechanisms of Sorafenib Resistance in Hepatocellular Carcinoma.- Radiological Assessment of Response to Palliative Treatments in Hepatocellular Carcinoma.- Sorafenib and Clinical Patterns of Resistance in hepatocellular carcinoma.- Overcoming Treatment Resistance in Hepatocellular Carcinoma: regorafenib and lessons from other malignancies.Autoren-Porträt
Augusto Villanueva, MD, PhD, is Assistant Professor, Division of Liver Diseases, Liver Cancer Program, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine, NYC.
Bibliographische Angaben
- 2017, 1st ed. 2017, XIII, 147 Seiten, 147 farbige Abbildungen, Masse: 16 x 24,1 cm, Gebunden, Englisch
- Herausgegeben: Augusto Villanueva
- Verlag: Springer, Berlin
- ISBN-10: 3319561960
- ISBN-13: 9783319561967
- Erscheinungsdatum: 27.07.2017
Sprache:
Englisch
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