The Biology of Tumors

1. The Role for ink4a in Melanoma Pathogenesis: One Gene, Two Products, Multiple Pathways.- 2. Identification and Characterization of Collaborating Oncogenes in Compound Mutant Mice.- 3. The Transcription Factor B-Myb Is Phosphorylated and Activated by Cyclin A/Cdk2.- 4. Distinct Dynamics and Regulatory Signal Transduction of Cell Migration: Lessons from Dendritic Cells, Tumor Cells, and T Lymphocytes.- 5. Genomic Instability in Sporadic Colorectal Cancer: A Destabilized Genome Producing Accelerated Cellular Evolution as the Fundamental Nature of Cancer.- 6. APC and the Early Events of Colon Cancer.- 7. Genome Scanning and Gene Discovery in Breast and Ovarian Cancer.- 8. Failure of Tumor Immunity Resulting from Inaccessibility of Activated Lymphocytes to Solid Tumors: The Possible Role of the Endothelium.- 9. Deciphering Molecular Circuitry Using High-Density DNA Arrays.- 10. Use of cDNA Microarrays to Assess DNA Gene Expression Patterns in Cancer.- 11. EH, a Novel Protein: Protein Interaction Domain.- 12. Deregulation of Cyclin D1 in Cancer.- 13. Dysregulation of Programmed Cell Death in Cancer toward a Molecular Understanding of Bcl-2.- 14. Characterization of Antigens Recognized by T Cells on Human Tumors.- 15. Identification of Human Tumor Antigens Using the B-Cell Repertoire.- 16. T Cell Tolerance versus Tumor Immunity or Autoimmunity.- 17. Manipulation of T Cell Activation in the Anti-Tumor Immune Response.- General Discussion.- 18. Cytokines and Tumor Immunogenicity: Toward an Appropriate Cancer Vaccine.- 19. T-Cell and NK-Mediated Surveillance of Cancer: A Delicate Balancing Act.- 20. Regulation of Leukocyte-Endothelial Cell Interactions in Tumor Immunity.- 21. Role of Endothelial versus Smooth Muscle Cells in Blood Vessel Formation.- 22. The Role of Vascular Endothelial Growth Factor in Tumor Angiogenesis.- 23. Tumor Microcirculation: Role in Delivery of Molecular and Cellular Medicine.