Tight Junctions in Inflammation and Cancer

ongoing investigations to understand the molecular details of the role of this protein in the regulation of intestinal homeostasis and pathologies have resulted in publications in Gastroenterology, GUT, Cancer Research, Mucosal Biology, Oncogene, etc.. In 2015, she demonstrated the role of Claudin-7 as a tumor suppressor in colorectal cancer, and this paper has received great attention. Her studies also focus on determining the role of cancer stem cells (CSCs) in colon cancer metastasis and chemoresistance. In this course, her group has generated novel reagents, genetically modified cell lines, and multiple mouse models with specific modification of claudin-1 and claudin-7 proteins alone or in association with other significant co-founders but also established our leadership in this field of investigation. As PI or co-Investigator on federally funded grants, she laid the groundwork for the proposed research to perform these studies and have the expertise, leadership, and motivation necessary to successfully carry out the proposed work. In addition, a member of the iCaRe2 Biobank/Biorepository has access to a "state of the art" patient cohort of CRC samples. As principal investigator or co-Investigator on federal, regional, and local grant funding, including NIH-R21, R01 and VA-merit awards aimed at intestinal pathologies and cancer, she effectively demonstrates leadership as the PI of this unique PI multi-disciplinary grant proposal.

Dr. Mohammad Haris is an associate professor at the Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA. He leads the molecular and metabolic imaging research program to develop novel MR imaging methods to image and diagnose various human diseases at their incipient stage. His additional role provides interdisciplinary training projects and an educational environment on biomedical imaging to undergraduat