TRP Channels in Drug Discovery
Volume I
(Sprache: Englisch)
Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has...
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Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention. TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field. Volume I presents a series of state-of-the-art minireviews on the most interesting TRP channels (from TRPA1 to TRPV4), as well as TRP-related protocols involving airways and the genitourinary tract. Written for the Methods in Pharmacology and Toxicology(TM) series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab.
Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.
Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.
Klappentext zu „TRP Channels in Drug Discovery “
Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention. TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field. Volume I presents a series of state-of-the-art minireviews on the most interesting TRP channels (from TRPA1 to TRPV4), as well as TRP-related protocols involving airways and the genitourinary tract. Written for the Methods in Pharmacology and Toxicology¿ series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab. Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.
Inhaltsverzeichnis zu „TRP Channels in Drug Discovery “
Part I: Introduction 1. Introduction to TRPs: A Quest for Novel Drug Targets Bernd Nilius 2. TRP-Mediated Cytoskeletal Reorganization: Implications for Disease and Drug Development Chandan Goswami Part II: TRP Channels, from A1 to V4 3. TRPA1 in Drug Discovery Jun Chen, Steve McGaraughty, and Philip R. Kym 4. Canonical Transient Receptor Potential Channel (TRPC) Expression, Regulation, and Function in Vascular and Airway Diseases Brij B. Singh, Christina M. Pabelick, and Y.S. Prakash 5. TRPM2 Function and Potential as a Drug Target Barbara A. Miller 6. The Ca2+-Activated Monovalent Cation Selective Channels TRPM4 and TRPM5 Colsoul Barbara, Kecskes Miklos, Philippaert Koenraad, Menigoz Aurelie, and Vennekens Rudi 7. The Emerging Role of TRPM7 in the Regulation of Magnesium Homeostasis Vladimir Chubanov, Jonathan T. Eggenschwiler, Thomas Gudermann, and Alexey G. Ryazanov 8. TRPM8 Channels as Potential Therapeutic Targets for Pain, Analgesia, and Thermoregulation David D. McKemy 9. TRPML Channels in Function, Disease, and Prospective Therapies David A. Zeevi 10. The TRPP Signalling Module: TRPP2/Polycystin 1 and TRPP2/PKD1L1 Alexis Hofherr 11. TRPV1 as a Polymodal Sensor: Potential to Discover TRPV1 Antagonists Selective for Specific Activating
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Modalities Olivier Radresa, Stephen Zicha, William Brown, and Jennifer M.A. Laird 12. Nociceptive and Non-Nociceptive Roles of TRPV3 and Its ¿Druggability¿ Sungjae Yoo and Sun Wook Hwang 13. TRPV4 and Drug Discovery Fabien Vincent and Matthew A.J. Duncton Part III: TRPs and Airways 14. TRP Expression and Function in the Lung Airways Alexander Dietrich and Thomas Gudermann 15. Hypoxia-Dependent TRP Channel Function in Pulmonary Arterial Smooth Muscle Cells Beate Fuchs, Hermann Kalwa, Norbert Weissmann, Thomas Gudermann, and Alexander Dietrich 16. Endotoxin-Induced Airway Inflammation and Asthma Models Zsuzsanna Helyes and Zsófia Hajna 17. Enhanced Cough, Animal Models Raffaele Gatti, Pamela Pedretti, Romina Nassini, and Marcello Trevisani 18. Capsaicin Inhalation Test in Man Eva Millqvist Part IV: TRPs and the Genitourinary (GU) Tract 19. TRP Channels in the Genitourinary (GU) Tract Ana Charrua and Francisco Cruz 20. Animal Models of Cystitis Célia D. Cruz and António Avelino 21. Overactive Bladder Models Roberto Soler, Lysanne Campeau, Claudius Füllhase, and Karl-Erik Andersson Alexis Hofherr 11. TRPV1 as a Polymodal Sensor: Potential to Discover TRPV1 Antagonists Selective for Specific Activating Modalities Olivier Radresa, Stephen Zicha, William Brown, and Jennifer M.A. Laird 12. Nociceptive and Non-Nociceptive Roles of TRPV3 and Its ¿Druggability¿ Sungjae Yoo and Sun Wook Hwang 13. TRPV4 and Drug Discovery Fabien Vincent and Matthew A.J. Duncton Part III: TRPs and Airways 14. TRP Expression and Function in the Lung Airways Alexander Dietrich and Thomas Gudermann 15. Hypoxia-Dependent TRP Channel Function in Pulmonary Arterial Smooth Muscle Cells Beate Fuchs, Hermann Kalwa, Norbert Weissmann, Thomas Gudermann, and Alexander Dietrich 16. Endotoxin-Induced Airway Inflammation and Asthma Models Zsuzsanna Helyes and Zsófia Hajna 17. Enhanced Cough, Animal Models Raffaele Gatti, Pamela Pedretti, Romina Nassini, and Marcello Trevisani 18. Capsaicin Inhalation Test in Man Eva Millqvist Part IV: TRPs and the Genitourinary (GU) Tract 19. TRP Channels in the Genitourinary (GU) Tract Ana Charrua and Francisco Cruz 20. Animal Models of Cystitis Célia D. Cruz and António Avelino 21. Overactive Bladder Models Roberto Soler, Lysanne Campeau, Claudius Füllhase, and Karl-Erik Andersson Olivier Radresa, Stephen Zicha, William Brown, and Jennifer M.A. Laird 12. Nociceptive and Non-Nociceptive Roles of TRPV3 and Its ¿Druggability¿ Sungjae Yoo and Sun Wook Hwang 13. TRPV4 and Drug Discovery Fabien Vincent and Matthew A.J. Duncton Part III: TRPs and Airways 14. TRP Expression and Function in the Lung Airways Alexander Dietrich and Thomas Gudermann 15. Hypoxia-Dependent TRP Channel Function in Pulmonary Arterial Smooth Muscle Cells Beate Fuchs, Hermann Kalwa, Norbert Weissmann, Thomas Gudermann, and Alexander Dietrich 16. Endotoxin-Induced Airway Inflammation and Asthma Models Zsuzsanna Helyes and Zsófia Hajna 17. Enhanced Cough, Animal Models Raffaele Gatti, Pamela Pedretti, Romina Nassini, and Marcello Trevisani 18. Capsaicin Inhalation Test in Man Eva Millqvist Part IV: TRPs and the Genitourinary (GU) Tract 19. TRP Channels in the Genitourinary (GU) Tract Ana Charrua and Francisco Cruz 20. Animal Models of Cystitis Célia D. Cruz and António Avelino 21. Overactive Bladder Models Roberto Soler, Lysanne Campeau, Claudius Füllhase, and Karl-Erik Andersson Sungjae Yoo and Sun Wook Hwang 13. TRPV4 and Drug Discovery Fabien Vincent and Matthew A.J. Duncton Part III: TRPs and Airways 14. TRP Expression and Function in the Lung Airways Alexander Dietrich and Thomas Gudermann 15. Hypoxia-Dependent TRP Channel Function in Pulmonary Arterial Smooth Muscle Cells Beate Fuchs, Hermann Kalwa, Norbert Weissmann, Thomas Gudermann, and Alexander Dietrich 16. Endotoxin-Induced Airway Inflammation and Asthma Models Zsuzsanna Helyes and Zsófia Hajna 17. Enhanced Cough, Animal Models Raffaele Gatti, Pamela Pedretti, Romina Nassini, and Marcello Trevisani 18. Capsaicin Inhalation Test in Man Eva Millqvist Part IV: TRPs and the Genitourinary (GU) Tract 19. TRP Channels in the Genitourinary (GU) Tract Ana Charrua and Francisco Cruz 20. Animal Models of Cystitis Célia D. Cruz and António Avelino 21. Overactive Bladder Models Roberto Soler, Lysanne Campeau, Claudius Füllhase, and Karl-Erik Andersson Fabien Vincent and Matthew A.J. Duncton Part III: TRPs and Airways 14. TRP Expression and Function in the Lung Airways Alexander Dietrich and Thomas Gudermann 15. Hypoxia-Dependent TRP Channel Function in Pulmonary Arterial Smooth Muscle Cells Beate Fuchs, Hermann Kalwa, Norbert Weissmann, Thomas Gudermann, and Alexander Dietrich 16. Endotoxin-Induced Airway Inflammation and Asthma Models Zsuzsanna Helyes and Zsófia Hajna 17. Enhanced Cough, Animal Models Raffaele Gatti, Pamela Pedretti, Romina Nassini, and Marcello Trevisani 18. Capsaicin Inhalation Test in Man Eva Millqvist Part IV: TRPs and the Genitourinary (GU) Tract 19. TRP Channels in the Genitourinary (GU) Tract Ana Charrua and Francisco Cruz 20. Animal Models of Cystitis Célia D. Cruz and António Avelino 21. Overactive Bladder Models Roberto Soler, Lysanne Campeau, Claudius Füllhase, and Karl-Erik Andersson Raffaele Gatti, Pamela Pedretti, Romina Nassini, and Marcello Trevisani 18. Capsaicin Inhalation Test in Man Eva Millqvist Part IV: TRPs and the Genitourinary (GU) Tract 19. TRP Channels in the Genitourinary (GU) Tract Ana Charrua and Francisco Cruz 20. Animal Models of Cystitis Célia D. Cruz and António Avelino 21. Overactive Bladder Models Roberto Soler, Lysanne Campeau, Claudius Füllhase, and Karl-Erik Andersson Eva Millqvist Part IV: TRPs and the Genitourinary (GU) Tract 19. TRP Channels in the Genitourinary (GU) Tract Ana Charrua and Francisco Cruz 20. Animal Models of Cystitis Célia D. Cruz and António Avelino 21. Overactive Bladder Models Roberto Soler, Lysanne Campeau, Claudius Füllhase, and Karl-Erik Andersson 19. TRP Channels in the Genitourinary (GU) Tract Ana Charrua and Francisco Cruz 20. Animal Models of Cystitis Célia D. Cruz and António Avelino 21. Overactive Bladder Models Roberto Soler, Lysanne Campeau, Claudius Füllhase, and Karl-Erik Andersson Ana Charrua and Francisco Cruz 20. Animal Models of Cystitis Célia D. Cruz and António Avelino 21. Overactive Bladder Models Roberto Soler, Lysanne Campeau, Claudius Füllhase, and Karl-Erik Andersson Roberto Soler, Lysanne Campeau, Claudius Füllhase, and Karl-Erik Andersson
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Bibliographische Angaben
- 2012, 2012, XI, 446 Seiten, Masse: 18,3 x 26 cm, Gebunden, Englisch
- Herausgegeben: Arpad Szallasi, Tamás Bíró
- Verlag: Springer, Berlin
- ISBN-10: 162703076X
- ISBN-13: 9781627030762
- Erscheinungsdatum: 20.09.2012
Sprache:
Englisch
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