Protein Misfolding, Aggregation and Conformational Diseases
Part A: Protein Aggregation and Conformational Diseases
(Sprache: Englisch)
Research indicates that most neurodegenerative diseases, systemic amyloidoses and many others, arise from the misfolding and aggregation of an underlying protein. This is the first book to discuss significant achievements in protein structure-function...
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Klappentext zu „Protein Misfolding, Aggregation and Conformational Diseases “
Research indicates that most neurodegenerative diseases, systemic amyloidoses and many others, arise from the misfolding and aggregation of an underlying protein. This is the first book to discuss significant achievements in protein structure-function relationships in biochemistry, molecular biology and molecular medicine. The authors summarize recent progress in the understanding of the relationships between protein misfolding, aggregation and development of protein deposition disorders.
Inhaltsverzeichnis zu „Protein Misfolding, Aggregation and Conformational Diseases “
- Conformational prerequisites of amyloidogenesis- The generic nature of protein folding and misfolding
- Relative importance of hydrophobicity, net charge and secondary structure propensities in prtein aggregation
- Cytotoxic intermediates in the fibrillation pathway: AB oligomers in Alzheimer's disease as a case study
- Glycosoaminoglycans, proteoglycans and conformational disorders
- Apolipoproteins in different amyloidoses
- Oxidative stress and protein deposition diseases
- Protein aggregation in crowded environment
- Chaperones and conformational disorders
- The aggresome: proteasomes, inclusion bodies and protein aggregation
- Protein aggregation/deposition and ion channel formation and membrane damage
- Visualization of protein deposits in vivo
- Visualization of protein deposits in vitro
- Animcal and cell models of human neurodegenerative disorders
- Index.
Bibliographische Angaben
- 2006, 419 Seiten, Masse: 16,5 x 24,3 cm, Gebunden, Englisch
- Herausgegeben:Uversky, Vladimir N.; Fink, Anthony
- Herausgegeben: Vladimir N. Uversky, Anthony Fink
- Verlag: Springer
- ISBN-10: 038725918X
- ISBN-13: 9780387259185
Sprache:
Englisch
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